The role of A-kinase anchoring proteins in cancer development.

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_4FCBC01F49D8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The role of A-kinase anchoring proteins in cancer development.
Périodique
Cellular Signalling
Auteur(s)
Reggi E., Diviani D.
ISSN
1873-3913 (Electronic)
ISSN-L
0898-6568
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
40
Pages
143-155
Langue
anglais
Résumé
Cancer development is a multifactorial process resulting from the aberrant activation of multiple signaling pathways. It has become increasingly clear that the coordination of the signaling events leading to cancer formation and progression is under the control of macromolecular transduction complexes organized by scaffolding proteins. A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins involved in the spatio-temporal activation of pathways controlling cancer cell proliferation, cell survival, and invasion. Mutations or altered expression of AKAP coding genes results in unregulated signaling associated with oncogenesis, cancer maintenance, and metastasis. This review will focus on recent advances illustrating the role of AKAPs in cancer pathophysiology as well as on their potential as therapeutic targets.
Mots-clé
A-kinase anchoring protein (AKAP), Cancer, Cyclic AMP, Protein kinase A, Signal transduction
Pubmed
Web of science
Financement(s)
Fonds national suisse / Projets
Création de la notice
27/11/2017 17:16
Dernière modification de la notice
17/01/2020 6:18
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