Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_4FC1647735D3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae.
Périodique
Nature Communications
Auteur(s)
van Giesen L., Hernandez-Nunez L., Delasoie-Baranek S., Colombo M., Renaud P., Bruggmann R., Benton R., Samuel A.D., Sprecher S.G.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
7
Pages
10687
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Accurate perception of taste information is crucial for animal survival. In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stimuli of one specific gustatory modality associated with a stereotyped behavioural response, such as aversion or attraction. We show that GRNs of Drosophila larvae employ a surprisingly different mode of gustatory information coding. Using a novel method for calcium imaging in the larval gustatory system, we identify a multimodal GRN that responds to chemicals of different taste modalities with opposing valence, such as sweet sucrose and bitter denatonium, reliant on different sensory receptors. This multimodal neuron is essential for bitter compound avoidance, and its artificial activation is sufficient to mediate aversion. However, the neuron is also essential for the integration of taste blends. Our findings support a model for taste coding in larvae, in which distinct receptor proteins mediate different responses within the same, multimodal GRN.
Mots-clé
Animals, Choice Behavior, Drosophila Proteins/genetics, Drosophila melanogaster, Fluorescent Antibody Technique, Larva/physiology, Physical Stimulation, Quaternary Ammonium Compounds, Receptors, Cell Surface/genetics, Sensory Receptor Cells/physiology, Sucrose, Taste/physiology, Taste Buds/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/02/2016 17:12
Dernière modification de la notice
20/08/2019 14:05
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