Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study.
Details
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_4FBFDD398F1F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study.
Journal
Journal of cystic fibrosis
Working group(s)
Global CF Registry Collaboration
Contributor(s)
Kasmi I., Drali O., Burghart S., Lakatos-Krepcik A., Eder J., Jaksch P., Kainz K., Kallinger M., Leitner A., Mozdzen M., Pfleger A., Renner S., Stadlinger M., Thir C., Nuriyev E., Boboli H., De Wachter E., Dupont L., Gohy S., Hanssens L., Knoop C., Lammertyn E., Nowé V., Pirson J., Thimmesch M., Van Braeckel E., Van Hoorenbeeck K., Vanderhelst E., Filho E.P., Athanazio R.A., Martins V.C., Duarte M.C., Monte LFV, de Fuccio M.B., Knabben ASC, Melloti R., Meneses D.G., Petrova G., Tješić-Drinković D., Dugac A.V., Bambir I., Yiallouros P., Bilkova A., Drevinek P., Macek M., Olesen H.V., Pressler T., Fouda E.M., Nasr S., Weldetsadik A.Y., Al-Iede M., Abdrakhmanov O., Corvol H., Lemonnier-Videau L., Abely M., Piccini C.B., Belleguic C., Bihouee T., Billon Y., Bui S., Camara B., Cheraud M.C., Chiron R., Duet E.C., Cosson L., Dalphin M.L., Boucher I.D., De Miranda S., Deneuville E., Dubus J.C., Durieu I., Epaud R., Gerardin M., Grenet D., Houdouin V., Huet F., Reem K., Kessler R., Languepin J., Laurans M., Leroy S., Llerena C., Macey J., Mankikian J., Marguet C., Martin C., Mely L., Mittaine M., Murris-Espin M., Perisson C., Prevotat A., Ramel S., Rames C., Reix P., Revillon M., Reynaud-Gaubert M., Richaud-Thiriez B., Rittie J.L., Scalbert-Dujardin M., Sermet-Gaudelus I., Storni V., Tatopoulos A., Thouvenin G., Troussier F., Weiss L., Wizla N., Behl E.S., Brinkmann F., Claßen M., Graepler-Mainka U., Griese M., Grübl A., Hammermann J., Hebestreit H., Heinzmann A., Herz A., Kiefer A., Kinder B., Köster H., Kuhnert S., Mainz J., Mayer A., Naehrig S., Niehues T., Nüßlein T., Poplawska K., Ringshausen F., Rose M., Rosenecker J., Ruppel R., Scharschinger A., Schropp C., Schwarz C., Smaczny C., Sommerburg O., Sutharsan S., Stolz S., Thomas W., Wege S., Welzenbach B., Wollschläger B., Diamantea F., Hatziagorou E., Manika K., Cox D., Elnazir B., Fletcher G., Gunaratnam C., McKone E.F., Plant B.J., Cohen-Cymberknoh M., Gur M., Livnat G., Mei-Zahav M., Amato A., Ferrari G., Badolato R., Poli P., Battistini F., Donati V., Bignamini E., Folino A., Carnovale V., Castellani C., Casciaro R., Cimino G., Cipolli M., Lucca F., Collura M., Ficili F., Daccò V., Gagliano V., Pizzamiglio G., Mencarini V., Palladino N., Leonardi S., Rotolo N., Lucanto M.C., Quattromano E., Lucidi V., Majo F., Alghisi F., Ciciriello F., Manca A., Leonetti G., Maschio M., Messore B., Pantano S., Pisi G., Spaggiari C., Raia V., Laezza C., Ros M., Salvatore D., Taccetti G., Francalanci M., Vitullo P., Zolin A., Aleksejeva E., Malakauskas K., Misevičiene V., Charatsi A.M., la Barrière H., Altenburg J., Bannier M., Heijerman H., Janssens H., Koppelman G., van der Meer R., Merkus P., Nuijsink M., Terheggen S., van der Vaart H., Wesseling G.J., de Winter K., Danevska I.A., Maretti T.J., Fustik S., Dziecichowicz-Latała D., Wojsyk-Banaszak I., Wozniacki L., Amorim A., Santos ASA, Castanhinha S., Gamboa F., Silva T.R., Gonçalves F., Pereira L., Ciuca I., Silva S., Csilla-Enikö S., Stan I., Amelina E., Boitсova E., Chernyavskaya A., Gorinova Y., Krasovskiy S., Mukhina M., Sherman V., Simonova O., Kondratyeva E., Bérešová E., Bližnáková N., Kayserová H., Salobir B., Šelb J., Krivec U., Fernandez AJA, Fernàndez A.A., García F.B., Aparicio M.B., Corullón S.C., Cortell-Aznar I., Pérez I., Colomer JCI, Roig M.C., Pecellín I.D., Cáceres L.D., Paredes C.L., Gartner S., Martínez JRG, Labarga I.H., Girón-Moreno R.M., Nogueira E.J., Ferreiro A.L., Neyra A.L., Castro E.B., Galarraga L.M., de Vincente C.M., Navarro S.M., Nieto-Royo R., Fuster C.O., Pastor M.D., Pérez-Ruiz E., Prados-Sánchez C., Cancelo I.R., de Valbuena M.R., Asensi JRV, Santiago V.S., García P.F., Tawfeeq R.M., Banki A., Gilljam M., Krantz C., Lindberg U., Lindblad A., Clarenbach C., Steinack C., Hage R., Schuurmans M., Fischer R., Kusche R., Rochat I., Schuurmans M., Walter A.L., Kamalaporn H., Hamouda S., Tural D.A., Ozcelik U., Asfuroğlu P., Eyüboğlu T.Ş., Aslan A.T., Bingöl A., Çobanoğlu N., Ozcan G., Dogru D., Gökdemir Y., Köse M., Pekcan S., Cosgriff R.
ISSN
1873-5010 (Electronic)
ISSN-L
1569-1993
Publication state
Published
Issued date
09/2024
Peer-reviewed
Oui
Volume
23
Number
5
Pages
815-822
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).
This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV <sub>1</sub> ) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV <sub>1</sub> and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.
A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV <sub>1</sub> pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.
No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.
This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV <sub>1</sub> ) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV <sub>1</sub> and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.
A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV <sub>1</sub> pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.
No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.
Keywords
Humans, Cystic Fibrosis/physiopathology, Cystic Fibrosis/complications, COVID-19/physiopathology, COVID-19/complications, COVID-19/epidemiology, Nutritional Status, Female, Male, Retrospective Studies, Adult, Forced Expiratory Volume, Body Mass Index, SARS-CoV-2, Respiratory Function Tests/methods, COVID-19, Coronavirus, Cystic fibrosis
Pubmed
Open Access
Yes
Create date
20/09/2024 14:50
Last modification date
21/09/2024 6:14
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