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NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
Nature Reviews. Immunology
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS).
Animals, Anti-Inflammatory Agents/pharmacology, Antigen-Antibody Complex/immunology, Antigen-Antibody Complex/metabolism, Carrier Proteins/immunology, Carrier Proteins/metabolism, Humans, Inflammation/drug therapy, Inflammation/immunology, Interleukin-1/antagonists & inhibitors, Interleukin-1/immunology, Mice, Mice, Knockout, Reactive Oxygen Species/immunology, Reactive Oxygen Species/metabolism, Signal Transduction
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