18F-FDG PET metabolic-to-morphological volume ratio predicts PD-L1 tumour expression and response to PD-1 blockade in non-small-cell lung cancer.

Détails

ID Serval
serval:BIB_4F575C6723CE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
18F-FDG PET metabolic-to-morphological volume ratio predicts PD-L1 tumour expression and response to PD-1 blockade in non-small-cell lung cancer.
Périodique
European journal of nuclear medicine and molecular imaging
Auteur(s)
Jreige M., Letovanec I., Chaba K., Renaud S., Rusakiewicz S., Cristina V., Peters S., Krueger T., de Leval L., Kandalaft L.E., Nicod-Lalonde M., Romero P., Prior J.O., Coukos G., Schaefer N.
ISSN
1619-7089 (Electronic)
ISSN-L
1619-7070
Statut éditorial
Publié
Date de publication
08/2019
Peer-reviewed
Oui
Volume
46
Numéro
9
Pages
1859-1868
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Anti-PD-1/PD-L1 blockade can restore tumour-specific T-cell immunity and is an emerging therapy in non-small-cell lung cancer (NSCLC). We investigated the correlation between <sup>18</sup> F-FDG PET/CT-based markers and tumour tissue expression of PD-L1, necrosis and clinical outcome in patients receiving checkpoint inhibitor treatment.
PD-Li expression in biopsy or resection specimens from 49 patients with confirmed NSCLC was investigated by immunohistochemistry. Maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were obtained from <sup>18</sup> F-FDG PET/CT images. The ratio of metabolic to morphological lesion volumes (MMVR) and its association with PD-L1 expression in each lesion were calculated. The associations between histologically reported necrosis and <sup>18</sup> F-FDG PET imaging patterns and radiological outcome (evaluated by iRECIST) following anti-PD-1/PD-L1 therapy were also analysed. In 14 patients, the association between necrosis and MMVR and tumour immune contexture were analysed by multiple immunofluorescent (IF) staining for CD8, PD-1, granzyme B (GrzB) and NFATC2.
In total, 25 adenocarcinomas and 24 squamous cell carcinomas were analysed. All tumours showed metabolic <sup>18</sup> F-FDG PET uptake. MMVR was correlated inversely with PD-L1 expression in tumour cells. Furthermore, PD-L1 expression and low MMVR were significantly correlated with clinical benefit. Necrosis was correlated negatively with MMVR. Multiplex IF staining showed a greater frequency of activated CD8 <sup>+</sup> cells in necrotic tumours than in nonnecrotic tumours in both stromal and epithelial tumour compartments.
This study introduces MMVR as a new imaging biomarker and its ability to noninvasively capture increased PD-L1 tumour expression and predict clinical benefit from checkpoint blockade in NSCLC should be further evaluated.
Mots-clé
FDG, Imaging, NSCLC, PD-L1, PET/CT
Pubmed
Web of science
Création de la notice
24/06/2019 17:11
Dernière modification de la notice
02/09/2019 12:21
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