Article: article from journal or magazin.
The hairy and enhancer of split 1 is a negative regulator of the repressor element silencer transcription factor.
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and beta-cells. In this study, we hypothesized that REST expression is controlled by hairy and enhancer of split 1 (HES-1), a transcriptional repressor that plays an important role in brain and pancreas development. We identified several N elements (CTNGTG) within the promoter of REST and confirmed that HES-1 associates with the endogenous promoter of REST. Moreover, using a cells model that overexpress HES-1 and a combination of experimental approaches, we demonstrated that HES-1 reduces endogenous REST expression. Taken together, these results indicate that HES-1 is an upstream negative regulator of REST expression.
Basic Helix-Loop-Helix Transcription Factors, Down-Regulation, Gene Expression Regulation, Hela Cells, Homeodomain Proteins, Humans, Promoter Regions, Genetic, Repressor Proteins, Response Elements, Transcription Factors
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