Cerebral vasomotor reactivity is reduced in patients with erectile dysfunction.
Details
Serval ID
serval:BIB_4EDEDE1AB969
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cerebral vasomotor reactivity is reduced in patients with erectile dysfunction.
Journal
European Neurology
ISSN
1421-9913 (Electronic)
ISSN-L
0014-3022
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
60
Number
2
Pages
85-88
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
BACKGROUND: Erectile dysfunction (ED) is not only evidence of diffuse atherosclerosis but also an index of early endothelial damage. We investigated cerebrovascular reactivity, expression of early arterial damage, in patients with isolated ED (ED+) and controls (ED-).
MATERIALS AND METHODS: Fifteen ED+ and 15 ED- subjects, matched for age (ED+: 58+/-6, ED-: 59 +/- 4 years) and vascular risk factors, were submitted to carotid duplex ultrasound and transcranial Doppler. Cerebrovascular reactivity was assessed on both middle cerebral arteries simultaneously calculating (a) the total vasomotor range (VMR) measured after breath holding and hyperventilation and (b) the rate of change (VMR/CO(2)) after breath holding.
RESULTS: Carotid Duplex scanning showed a light carotid stenosis only in 3 (2 in the ED+ and 1 in the ED- group). No differences were observed in intima-media thickness between ED+ and ED-. Slightly slower mean middle cerebral artery flow velocities were observed in ED+ with respect to ED-. ED+ patients showed a reduced VMR (p < 0.001) and a slower VMR/CO(2) rate of change (p < 0.001) compared to ED-.
CONCLUSIONS: The reduced reactivity in patients with isolated ED may represent a marker of early cerebral vasomotor dysfunction due to subclinical endothelial damage.
MATERIALS AND METHODS: Fifteen ED+ and 15 ED- subjects, matched for age (ED+: 58+/-6, ED-: 59 +/- 4 years) and vascular risk factors, were submitted to carotid duplex ultrasound and transcranial Doppler. Cerebrovascular reactivity was assessed on both middle cerebral arteries simultaneously calculating (a) the total vasomotor range (VMR) measured after breath holding and hyperventilation and (b) the rate of change (VMR/CO(2)) after breath holding.
RESULTS: Carotid Duplex scanning showed a light carotid stenosis only in 3 (2 in the ED+ and 1 in the ED- group). No differences were observed in intima-media thickness between ED+ and ED-. Slightly slower mean middle cerebral artery flow velocities were observed in ED+ with respect to ED-. ED+ patients showed a reduced VMR (p < 0.001) and a slower VMR/CO(2) rate of change (p < 0.001) compared to ED-.
CONCLUSIONS: The reduced reactivity in patients with isolated ED may represent a marker of early cerebral vasomotor dysfunction due to subclinical endothelial damage.
Keywords
Blood Flow Velocity, Carotid Stenosis/complications, Carotid Stenosis/ultrasonography, Cerebrovascular Circulation, Cerebrovascular Disorders/complications, Cerebrovascular Disorders/physiopathology, Comorbidity, Early Diagnosis, Endothelium, Vascular/physiopathology, Erectile Dysfunction/complications, Erectile Dysfunction/physiopathology, Humans, Male, Middle Aged, Middle Cerebral Artery/physiopathology, Middle Cerebral Artery/ultrasonography, Risk, Tunica Intima/ultrasonography, Tunica Media/ultrasonography, Ultrasonography, Doppler, Duplex, Ultrasonography, Doppler, Transcranial, Vasomotor System/physiopathology, Vasomotor System/ultrasonography
Pubmed
Web of science
Create date
09/02/2015 13:02
Last modification date
20/08/2019 15:04
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