Le NO, un regulateur majeur de l'homeostasie glucidique et cardio-vasculaire. [NO, a major regulator of metabolic and cardiovascular homeostasis]

Details

Serval ID
serval:BIB_4ED8E774B335
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Le NO, un regulateur majeur de l'homeostasie glucidique et cardio-vasculaire. [NO, a major regulator of metabolic and cardiovascular homeostasis]
Journal
Revue Médicale de la Suisse Romande
Author(s)
Thalmann  S., Jayet  P. Y., Duplain  H., Turini  P., Sartori  C., Vollenweider  P., Scherrer  U.
ISSN
0035-3655 (Print)
Publication state
Published
Issued date
10/2004
Volume
124
Number
10
Pages
639-41
Notes
English Abstract
Journal Article
Review --- Old month value: Oct
Abstract
Obesity and insulin resistance are reaching epidemic proportions worldwide. Over the past decade, nitric oxide (NO) has emerged as a key player in the regulation of the metabolic and cardiovascular homeostasis. Here we will review recent data obtained in mice with disruption of the genes encoding for each of the three nitric oxide synthase isoforms. These data demonstrate that both defective and augmented NO synthesis have detrimental effects on the regulation of the metabolic and cardiovascular system. These observations provide the rationale for the use of NO-donors and/or inhibitors of NO overproduction in the treatment of insulin resistance.
Keywords
*Cardiovascular Physiology Homeostasis Humans *Insulin Resistance Metabolic Syndrome X/physiopathology Nitric Oxide/*pharmacology Nitric Oxide Synthase/*pharmacology Phenotype
Pubmed
Create date
25/01/2008 13:44
Last modification date
20/08/2019 14:04
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