Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Administration intra-vitréenne de liposomes pour la vectorisation de principes actifs [The use of liposomes as intravitreal drug delivery system].
Journal Français D'ophtalmologie
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Liposomes are vesicular lipidic systems allowing encapsulation of drugs. This article reviews the relevant issues in liposome structure (composition and size), and their influence on intravitreal pharmacokinetics. Liposome-mediated drug delivery to the posterior segment of the eye via intravitreal administration has been addressed by several authors and remains experimental. Liposomes have been used for intravitreal delivery of antibiotics, antivirals, antifungal drugs, antimetabolites, and cyclosporin. Encapsulation of these drugs within liposomes markedly increased their intravitreal half-life, and reduced their retinal toxicity. Liposomes have also shown an attractive potential for retinal gene transfer by intravitreal delivery of plasmids or oligonucleotides.
Administration, Topical, Biological Availability, Blood-Retinal Barrier, Drug Delivery Systems/methods, Gene Transfer Techniques, Half-Life, Humans, Liposomes/administration & dosage, Liposomes/chemistry, Metabolic Clearance Rate, Vitreous Body/drug effects, Vitreous Body/metabolism
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