Transfusion efficacy of apheresis platelet concentrates irradiated at the day of transfusion is significantly superior compared to platelets irradiated in advance.

Details

Serval ID
serval:BIB_4E9BCA0DC3B0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Transfusion efficacy of apheresis platelet concentrates irradiated at the day of transfusion is significantly superior compared to platelets irradiated in advance.
Journal
Transfusion Medicine and Hemotherapy
Author(s)
Julmy F., Ammann R.A., Fontana S., Taleghani B.M., Hirt A., Leibundgut K.
ISSN
1660-3796 (Print)
ISSN-L
1660-3796
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
41
Number
3
Pages
176-181
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
BACKGROUND: Gamma irradiation is currently the standard care to avoid transfusion-associated graft-versus-host disease. Guidelines on gamma irradiation of blood components state that platelets (PLTs) can be irradiated at any stage in their 5-day storage and can thereafter be stored up to their normal shelf life of 5 days after collection. In this study, we explored whether the timing of irradiation has an effect on transfusion efficacy of apheresis PLT concentrates (APCs).
METHODS: Based on the 1-hour percent PLT recovery (PPR1h), transfusion efficacy of 1,000 eligible APCs transfused to 144 children were evaluated retrospectively. PPR1h was compared in transfused APCs irradiated at the day of transfusion and APCs irradiated in advance.
RESULTS: In univariate analysis, transfusion efficacy of APCs irradiated in advance was significantly lower than that of APCs irradiated at the day of transfusion (mean PPR1h 27.7 vs. 35.0%; p = 0.007). This was confirmed in multivariate analysis (p = 0.030). Compared to non-irradiated APCs, transfusion efficacy of APCs irradiated at the day of transfusion was not significantly inferior (mean difference -2.8%; 95% CI -6.1 to 0.5%; p = 0.092), but APCs irradiated in advance were clearly less efficient (mean difference -8.1%; 95% CI -12.2 to -4.0%; p < 0.001).
CONCLUSION: Our data strongly support that APCs should not be irradiated in advance, 1.e., ≥24 h before transfusion.
Pubmed
Web of science
Open Access
Yes
Create date
09/11/2014 17:20
Last modification date
20/08/2019 14:04
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