Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
Details
Serval ID
serval:BIB_4E0C4E1AA94B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
Journal
Science
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Publication state
Published
Issued date
1998
Volume
282
Number
5388
Pages
490-493
Language
english
Abstract
Toxic epidermal necrolysis (TEN, Lyell's syndrome) is a severe adverse drug reaction in which keratinocytes die and large sections of epidermis separate from the dermis. Keratinocytes normally express the death receptor Fas (CD95); those from TEN patients were found to express lytically active Fas ligand (FasL). Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro. In a pilot study, 10 consecutive individuals with clinically and histologically confirmed TEN were treated with IVIG; disease progression was rapidly reversed and the outcome was favorable in all cases. Thus, Fas-FasL interactions are directly involved in the epidermal necrolysis of TEN, and IVIG may be an effective treatment.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Blocking/immunology, Antibodies, Blocking/therapeutic use, Antigens, CD95/immunology, Antigens, CD95/physiology, Apoptosis, Child, Dermis/pathology, Disease Progression, Epidermal Necrolysis, Toxic/pathology, Epidermal Necrolysis, Toxic/therapy, Epidermis/pathology, Fas Ligand Protein, Female, Humans, Immunoglobulins, Intravenous/therapeutic use, Jurkat Cells, Keratinocytes/metabolism, Keratinocytes/pathology, Male, Membrane Glycoproteins/metabolism, Middle Aged, Pilot Projects
Pubmed
Web of science
Create date
24/01/2008 16:18
Last modification date
20/08/2019 15:03