Article: article from journal or magazin.
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
Toxic epidermal necrolysis (TEN, Lyell's syndrome) is a severe adverse drug reaction in which keratinocytes die and large sections of epidermis separate from the dermis. Keratinocytes normally express the death receptor Fas (CD95); those from TEN patients were found to express lytically active Fas ligand (FasL). Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro. In a pilot study, 10 consecutive individuals with clinically and histologically confirmed TEN were treated with IVIG; disease progression was rapidly reversed and the outcome was favorable in all cases. Thus, Fas-FasL interactions are directly involved in the epidermal necrolysis of TEN, and IVIG may be an effective treatment.
Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Blocking/immunology, Antibodies, Blocking/therapeutic use, Antigens, CD95/immunology, Antigens, CD95/physiology, Apoptosis, Child, Dermis/pathology, Disease Progression, Epidermal Necrolysis, Toxic/pathology, Epidermal Necrolysis, Toxic/therapy, Epidermis/pathology, Fas Ligand Protein, Female, Humans, Immunoglobulins, Intravenous/therapeutic use, Jurkat Cells, Keratinocytes/metabolism, Keratinocytes/pathology, Male, Membrane Glycoproteins/metabolism, Middle Aged, Pilot Projects
Web of science
Last modification date