Effet de la bromocriptine sur le débit sanguin cérébral dans la maladie de Parkinson [Effect of bromocriptine on cerebral blood flow in Parkinson's disease].

Détails

ID Serval
serval:BIB_4DEF3014DBB7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effet de la bromocriptine sur le débit sanguin cérébral dans la maladie de Parkinson [Effect of bromocriptine on cerebral blood flow in Parkinson's disease].
Périodique
Revue Neurologique
Auteur(s)
Celsis P., Rascol O., Demonet J.F., Agniel A., Montastruc J.L., Marc-Vergnes J.P., Rascol A.
ISSN
0035-3787 (Print)
ISSN-L
0035-3787
Statut éditorial
Publié
Date de publication
1988
Volume
144
Numéro
5
Pages
367-371
Langue
français
Notes
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish
Résumé
We measured regional cerebral blood flow (CBF) with single photon emission computed tomography and Xenon 133 in 8 patients with Parkinson's disease (stages I or II) before and after acute oral administration of 10 mg bromocriptine. Moreover, Columbia University Rating scale and neuropsychological tests were assessed before and after drug administration. Bromocriptine induced a significant (p less than 0.01) increase in CBF (+ 12 p. 100) in all the regions studied unrelated to pCO2 variations. The Columbia motor scale score decreased (by 16 p. 100) whereas those on the neuropsychological tests did not vary. There was no relationship between the improvement in motor performance and the increase in CBF. The results suggest that the effect of bromocriptine on CBF is not mediated by an action on the major dopaminergic pathways in the brain but rather by a direct effect on dopaminergic receptors located on cerebral vessels.
Mots-clé
Administration, Oral, Bromocriptine/administration & dosage, Bromocriptine/pharmacology, Cerebrovascular Circulation/drug effects, Female, Humans, Male, Middle Aged, Parkinson Disease/drug therapy, Parkinson Disease/physiopathology
Pubmed
Web of science
Création de la notice
24/03/2013 14:00
Dernière modification de la notice
20/08/2019 15:03
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