Heritability and intrafamilial aggregation of arterial characteristics

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Serval ID
serval:BIB_4DCF8C6E96E0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Heritability and intrafamilial aggregation of arterial characteristics
Journal
Journal of Hypertension
Author(s)
Seidlerová Jitka, Bochud Murielle, Staessen Jan A., Cwynar Marcin, Dolejová Milena, Kuznetsova Tatiana, Nawrot Tim, Olszanecka Agnieszka, Stolarz Katarzyna, Thijs Lutgarde, Wojciechowska Wiktoria, Struijker-Boudier Harry A., Kawecka-Jaszcz Kalina, Elston Robert C., Fagard Robert, Filipovsk Jan
ISSN
0263-6352
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
26
Number
4
Pages
721-728
Language
english
Abstract
BACKGROUND: We investigated the heritability and familial aggregation of various indexes of arterial stiffness and wave reflection and we partitioned the phenotypic correlation between these traits into shared genetic and environmental components. METHODS: Using a family-based population sample, we recruited 204 parents (mean age, 51.7 years) and 290 offspring (29.4 years) from the population in Cracow, Poland (62 families), Hechtel-Eksel, Belgium (36), and Pilsen, the Czech Republic (50). We measured peripheral pulse pressure (PPp) sphygmomanometrically at the brachial artery; central pulse pressure (PPc), the peripheral augmentation indexes (PAIxs) and central augmentation indexes (CAIxs) by applanation tonometry at the radial artery; and aortic pulse wave velocity (PWV) by tonometry or ultrasound. In multivariate-adjusted analyses, we used the ASSOC and PROC GENMOD procedures as implemented in SAGE and SAS, respectively. RESULTS: We found significant heritability for PAIx, CAIx, PPc and mean arterial pressure ranging from 0.37 to 0.41; P </= 0.0001. The method of intrafamilial concordance confirmed these results; intrafamilial correlation coefficients were significant for all arterial indexes (r >/= 0.12; P </= 0.02) with the exception of PPc (r = -0.007; P = 0.90) in parent-offspring pairs. The sib-sib correlations were also significant for CAIx (r = 0.22; P = 0.001). The genetic correlation between PWV and the other arterial indexes were significant (rhoG >/= 0.29; P < 0.0001). The corresponding environmental correlations were only significantly positive for PPp (rhoE = 0.10, P = 0.03). CONCLUSION: The observation of significant intrafamilial concordance and heritability of various indexes of arterial stiffness as well as the genetic correlations among arterial phenotypes strongly support the search for shared genetic determinants underlying these traits.
Keywords
Adult, Aged, Aorta/physiology, Arteries/physiology, Belgium, Blood Pressure/genetics, Brachial Artery/physiology, Czech Republic, Environment, Family, Female, Humans, Hypertension/genetics, Hypertension/physiopathology, Male, Middle Aged, Phenotype, Poland, Pulsatile Flow/physiology, Radial Artery/physiology
Pubmed
Web of science
Open Access
Yes
Create date
10/04/2008 15:14
Last modification date
20/08/2019 14:03
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