A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
Details
Serval ID
serval:BIB_4DA4C702A005
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
Journal
Cell
ISSN
0092-8674 (Print)
Publication state
Published
Issued date
09/1998
Volume
94
Number
5
Pages
625-34
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep 4
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep 4
Abstract
Caveolin-1 functions as a membrane adaptor to link the integrin alpha subunit to the tyrosine kinase Fyn. Upon integrin ligation, Fyn is activated and binds, via its SH3 domain, to Shc. Shc is subsequently phosphorylated at tyrosine 317 and recruits Grb2. This sequence of events is necessary to couple integrins to the Ras-ERK pathway and promote cell cycle progression. These findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth.
Keywords
3T3 Cells
*Adaptor Proteins, Signal Transducing
*Adaptor Proteins, Vesicular Transport
Animals
Caveolin 1
*Caveolins
Cell Division/physiology
Cell Fractionation
Cells, Cultured
GRB2 Adaptor Protein
Integrins/isolation & purification/*physiology
Membrane Proteins/isolation & purification/*physiology
Mice
Mitogen-Activated Protein Kinases/physiology
Octoxynol
Protein-Tyrosine Kinases/isolation & purification/*physiology
Proteins/physiology
Proto-Oncogene Proteins/chemistry/isolation & purification/*physiology
Proto-Oncogene Proteins c-fyn
Rats
Rats, Inbred F344
Signal Transduction/*physiology
Solubility
Thyroid Gland/cytology
ras Proteins/physiology
src Homology Domains/physiology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 9:33
Last modification date
20/08/2019 15:02