PURPOSE: In this study, we evaluated the results of arthroscopic stabilization of the shoulder using knotless anchors and the lesions associated with anterior-inferior labrum avulsion. TYPE OF STUDY: Retrospective clinical study. METHODS: Twenty consecutive patients affected with anterior unidirectional post-traumatic shoulder instability were treated with arthroscopic reconstruction using knotless anchors. During the surgical procedure, associated lesions such as superior labrum anterior posterior (SLAP) (15%) and rotator interval (15%) were repaired. The patients were evaluated at a mean follow-up of 43 months. RESULTS: Eighty percent of patients resumed sports activity without any limitation and 90% of patients were satisfied with the results of surgery. One patient (5%) had a recurrent dislocation; this patient resumed a contact sport activity despite medical advice. One patient (5%) related signs of shoulder insecurity at the extreme degree of abduction and external rotation; this patient had resumed sports activity with a moderate limitation and was the only patient who was not completely satisfied with the results of surgery. No significant difference was observed between the operated and the contralateral shoulder according to the Rowe and Constant scores. The mean loss of external rotation was 3 degrees . We did not have any cases of anchor loosening, nor did we find signs of shoulder degenerative osteoarthritis on the radiographs. CONCLUSIONS: The knotless anchor seems to be a viable alternative for arthroscopic labrum repair, allowing a good capsular shift. Arthroscopic management of shoulder instability allows us to diagnose and treat associated lesions, thus improving the success rate of this type of surgery. LEVEL OF EVIDENCE: Level IV, case series.