Physiological Whole-Brain Distribution of [<sup>18</sup>F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis.
Details
Serval ID
serval:BIB_4D212A136908
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Physiological Whole-Brain Distribution of [<sup>18</sup>F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis.
Journal
Molecular imaging and biology
ISSN
1860-2002 (Electronic)
ISSN-L
1536-1632
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
21
Number
3
Pages
549-557
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
6-[ <sup>18</sup> F]fluoro-L-DOPA ([ <sup>18</sup> F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [ <sup>18</sup> F]FDOPA, expressed relative to the occipital background level, varies according to age and gender.
One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [ <sup>18</sup> F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p < 0.05 (corrected) and p < 0.005 (uncorrected, k cluster > 125).
Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women).
The uptake index of [ <sup>18</sup> F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.
One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [ <sup>18</sup> F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p < 0.05 (corrected) and p < 0.005 (uncorrected, k cluster > 125).
Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women).
The uptake index of [ <sup>18</sup> F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.
Keywords
Adult, Age Factors, Aged, Aged, 80 and over, Brain/diagnostic imaging, Brain/physiology, Corpus Striatum/metabolism, Dihydroxyphenylalanine/analogs & derivatives, Dihydroxyphenylalanine/chemistry, Female, Humans, Linear Models, Male, Middle Aged, Positron-Emission Tomography, Tissue Distribution, Young Adult, Age, Gender, Quantitative analysis, Template, [18F]FDOPA PET
Pubmed
Web of science
Create date
07/08/2018 9:34
Last modification date
26/06/2020 6:21
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