Article: article from journal or magazin.
The biochemistry of drug metabolism-an introduction: part 7. Intra-individual factors affecting drug metabolism.
Chemistry & Biodiversity
1477-1660, table of contents
This review on intra-individual factors affecting drug metabolism completes our series on the biochemistry of drug metabolism. The article presents the molecular mechanisms causing intra-individual differences in enzyme expression and activity. They include enzyme induction by transcriptional activation and enzyme inhibition on the protein level. The influencing factors are of physiological, pathological, or external origin. Tissue characteristics and developmental age strongly influence enzyme-expression patterns. Further influencing factors are pregnancy, disease, or biological rhythms. Xenobiotics, drugs, constituents of herbal remedies, food constituents, ethanol, and tobacco can all influence enzyme expression or activity and, hence, affect drug metabolism.
Pregnane-X-Receptor, Constitutive Androstane Receptor, Aryl-Hydrocarbon Receptor, Orphan Nuclear Receptor, Human Liver-Microsomes, Mechanism-Based Inactivation, St-Johns-Wort, Enriched Transcription Factors, Human Cytochrome-P450 Enzymes, Antioxidant Response Element
Web of science
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