The biochemistry of drug metabolism-an introduction: part 7. Intra-individual factors affecting drug metabolism.

Details

Serval ID
serval:BIB_4D00FBC2C87F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The biochemistry of drug metabolism-an introduction: part 7. Intra-individual factors affecting drug metabolism.
Journal
Chemistry & Biodiversity
Author(s)
Krämer S.D., Testa B.
ISSN
1612-1880[electronic]
Publication state
Published
Issued date
2009
Volume
6
Number
10
Pages
1477-1660, table of contents
Language
english
Abstract
This review on intra-individual factors affecting drug metabolism completes our series on the biochemistry of drug metabolism. The article presents the molecular mechanisms causing intra-individual differences in enzyme expression and activity. They include enzyme induction by transcriptional activation and enzyme inhibition on the protein level. The influencing factors are of physiological, pathological, or external origin. Tissue characteristics and developmental age strongly influence enzyme-expression patterns. Further influencing factors are pregnancy, disease, or biological rhythms. Xenobiotics, drugs, constituents of herbal remedies, food constituents, ethanol, and tobacco can all influence enzyme expression or activity and, hence, affect drug metabolism.
Keywords
Pregnane-X-Receptor, Constitutive Androstane Receptor, Aryl-Hydrocarbon Receptor, Orphan Nuclear Receptor, Human Liver-Microsomes, Mechanism-Based Inactivation, St-Johns-Wort, Enriched Transcription Factors, Human Cytochrome-P450 Enzymes, Antioxidant Response Element
Pubmed
Web of science
Create date
20/11/2009 11:07
Last modification date
20/08/2019 15:01
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