Peri-implant bone remodeling after total hip replacement combined with systemic alendronate treatment: a finite element analysis.

Détails

ID Serval
serval:BIB_4CA0D8349F40
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Peri-implant bone remodeling after total hip replacement combined with systemic alendronate treatment: a finite element analysis.
Périodique
Computer Methods in Biomechanics and Biomedical Engineering
Auteur(s)
Peter B., Ramaniraka N., Rakotomanana L.R., Zambelli P.Y., Pioletti D.P.
ISSN
1025-5842 (Print)
ISSN-L
1025-5842
Statut éditorial
Publié
Date de publication
04/2004
Peer-reviewed
Oui
Volume
7
Numéro
2
Pages
73-78
Langue
anglais
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Validation Studies
Publication Status: ppublish
Résumé
In order to decrease the peri-implant bone loss during the life-time of the implant, oral use of anti-osteoporosis drugs (like bisphosphonates) has been suggested. In this study, bone remodeling parameters identified from clinical trials of alendronate were used to simulate the effect of those drugs used after total hip arthroplasty on the peri-implant bone density. Results of the simulation show that the oral administrated drugs increase bone density around the implant and decreases, at the same time, the micromovements between the implant and the surrounding bone tissue. Incorporation of drug effect in numerical studies of bone remodeling is a promising tool especially to predetermine safe bisphosphonate doses that could be used with orthopedic implants.
Mots-clé
Administration, Oral, Alendronate/administration & dosage, Arthroplasty, Replacement, Hip/adverse effects, Bone Density/drug effects, Bone Density/physiology, Bone Remodeling/drug effects, Bone Remodeling/physiology, Computer Simulation, Dose-Response Relationship, Drug, Drug Therapy, Computer-Assisted/methods, Equipment Failure Analysis/methods, Femur/drug effects, Femur/physiopathology, Finite Element Analysis, Hip Prosthesis/adverse effects, Humans, Models, Biological, Osteoporosis/etiology, Osteoporosis/physiopathology, Prosthesis Failure, Prosthesis-Related Infections/etiology, Prosthesis-Related Infections/physiopathology, Treatment Outcome
Pubmed
Création de la notice
28/01/2008 12:29
Dernière modification de la notice
20/08/2019 14:01
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