Prospective associations of depression subtypes with cardio-metabolic risk factors in the general population.

Détails

Ressource 1Télécharger: 5_27725658_Postprint.pdf (754.35 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_4C8F5CF44AE3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prospective associations of depression subtypes with cardio-metabolic risk factors in the general population.
Périodique
Molecular psychiatry
Auteur(s)
Lasserre A.M., Strippoli M.F., Glaus J., Gholam-Rezaee M., Vandeleur C.L., Castelao E., Marques-Vidal P., Waeber G., Vollenweider P., Preisig M.
ISSN
1476-5578 (Electronic)
ISSN-L
1359-4184
Statut éditorial
Publié
Date de publication
07/2017
Peer-reviewed
Oui
Volume
22
Numéro
7
Pages
1026-1034
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The mechanisms and temporal sequence underlying the association between major depressive disorder (MDD) and cardio-metabolic diseases are still poorly understood. Recent research suggests subtyping depression to study the mechanisms underlying its association with biological correlates. Accordingly, our aims were to (1) assess the prospective associations of the atypical, melancholic and unspecified subtypes of MDD with changes of fasting glucose, high-density lipoprotein-cholesterol, triglycerides, systolic blood pressure and the incidence of the metabolic syndrome, (2) determine the potential mediating role of inflammatory marker or adipokine concentrations, eating behaviors and changes in waist circumference during follow-up. Data stemmed from CoLaus|PsyCoLaus, a prospective cohort study including 35-66-year-old randomly selected residents of an urban area. Among the Caucasian participants who underwent the physical and psychiatric baseline evaluations, 2813 (87% participation rate) also accepted the physical follow-up exam (mean follow-up duration=5.5 years). Symptoms of mental disorders were elicited using a semi-structured interview. The atypical MDD subtype, and only this subtype, was prospectively associated with a higher incidence of the metabolic syndrome (OR=2.49; 95% CI 1.30-4.77), a steeper increase of waist circumference (β=2.41; 95% CI 1.19-3.63) and independently of this, with a steeper increase of the fasting glucose level (β=131; 95% CI 38-225) during follow-up. These associations were not attributable to or mediated by inflammatory marker or adipokine concentrations, eating behaviors, comorbid psychiatric disorders or lifestyle factors. Accordingly, our results further support the subtyping of MDD and highlight the particular need for prevention and treatment of metabolic consequences in patients with atypical MDD.

Mots-clé
Adult, Blood Glucose/metabolism, Cholesterol, HDL/blood, Comorbidity, Depression/complications, Depressive Disorder, Major/classification, Depressive Disorder, Major/complications, Depressive Disorder, Major/diagnosis, Depressive Disorder, Major/metabolism, Female, Heart Diseases/genetics, Heart Diseases/metabolism, Humans, Incidence, Life Style, Male, Metabolic Diseases/genetics, Metabolic Diseases/metabolism, Metabolic Syndrome X/epidemiology, Middle Aged, Prospective Studies, Risk Factors, Switzerland, Triglycerides/blood, Waist Circumference
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/03/2017 9:16
Dernière modification de la notice
27/09/2019 8:54
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