Impact of deleterious mutations, sexually antagonistic selection, and mode of recombination suppression on transitions between male and female heterogamety.

Détails

ID Serval
serval:BIB_4C83D16AEB79
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impact of deleterious mutations, sexually antagonistic selection, and mode of recombination suppression on transitions between male and female heterogamety.
Périodique
Heredity
Auteur(s)
Saunders P.A., Neuenschwander S., Perrin N.
ISSN
1365-2540 (Electronic)
ISSN-L
0018-067X
Statut éditorial
Publié
Date de publication
27/04/2019
Peer-reviewed
Oui
Volume
123
Pages
419-428
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Résumé
Deleterious mutations accumulating on non-recombining Y chromosomes can drive XY to XY turnovers, as they allow to replace the old mutation-loaded Y by a new mutation-free one. The same process is thought to prevent XY to ZW turnovers, because the latter requires fixation of the ancestral Y, assuming dominance of the emergent feminizing mutation. Using individual-based simulations, we explored whether and how an epistatically dominant W allele can spread in a young XY system that gradually accumulates deleterious mutations. We also investigated how sexually antagonistic (SA) polymorphism on the ancestral sex chromosomes and the mechanism controlling X-Y recombination suppression affect these transitions. In contrast with XY to XY turnovers, XY to ZW turnovers cannot be favored by Y chromosome mutation load. If the arrest of X-Y recombination depends on genotypic sex, transitions are strongly hindered by deleterious mutations, and totally suppressed by very small SA cost, because deleterious mutations and female-detrimental SA alleles would have to fix with the Y. If, however, the arrest of X-Y recombination depends on phenotypic sex, X and Y recombine in XY ZW females, allowing for the purge of Y-linked deleterious mutations and loss of the SA polymorphism, causing XY to ZW turnovers to occur at the same rate as in the absence of deleterious and sex-antagonistic mutations. We generalize our results to other types of turnovers (e.g., triggered by non-dominant sex-determining mutations) and discuss their empirical relevance.
Mots-clé
sex chromosomes turnovers, mutation load, inversions, achiasmy, simulations, quantiNemo
Pubmed
Création de la notice
24/03/2019 10:04
Dernière modification de la notice
21/08/2019 6:36
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