Anti-Saccharomyces cerevisiae mannan antibodies in familial Crohn’s disease

Details

Serval ID
serval:BIB_4C7BA7D6ABA3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Anti-Saccharomyces cerevisiae mannan antibodies in familial Crohn’s disease
Journal
Am J Gastroenterol
Author(s)
Sendid B., Quinton J. F., Charrier G., Goulet O., Cortot A., Grandbastien B., Poulain D., Colombel J. F.
Publication state
Published
Issued date
08/1998
Volume
93
Number
8
Pages
1306-10
Language
english
Abstract
OBJECTIVE: Anti-Saccharomyces cerevisiae mannan antibodies (ASCA) are associated with Crohn’s disease. The aim of this study was to determine the prevalence of ASCA in families in which at least two members were affected with Crohn’s disease. METHODS: A total of 20 families including two (n=15) or more (n=5) patients with Crohn’s disease were tested for ASCA with use of an ELISA method. Overall, 51 affected members, 66 healthy first degree relatives, and 163 healthy control subjects were studied. RESULTS: ASCA were detected in 35 of 51 (69%) patients with Crohn’s disease and in 13 of 66 (20%) healthy relatives versus one of 163 healthy control subjects (p < 0.0001 and p < 0.001). ASCA-positive relatives were distributed in 12 of 20 families. ASCA were present in eight healthy parents and four healthy siblings. The prevalence of ASCA in relatives did not depend on the ASCA status of affected members. CONCLUSION: ASCA in 20% of healthy first degree relatives of patients with Crohn’s disease suggest that these antibodies might be a subclinical marker for Crohn’s disease in families. Whether ASCA reflect environmental or genetic factors or a combination of both is unknown.
Keywords
Adolescent, Adult, Aged, Antibodies, Fungal/*blood, Biomarkers/blood, Chi-Square Distribution, Child, Crohn Disease/epidemiology/*genetics/*immunology, Enzyme-Linked Immunosorbent Assay/methods/statistics & numerical data, Female, Genetic Markers, Humans, Male, Mannans/*immunology, Middle Aged, Pedigree, Prevalence, Saccharomyces cerevisiae/*immunology
Create date
18/07/2019 12:48
Last modification date
21/08/2019 5:33
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