Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning.

Details

Serval ID
serval:BIB_4C796391BB4F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning.
Journal
Radiotherapy and Oncology
Author(s)
Musat Elena, Roelofs Erik, Bar-Deroma Raquel, Fenton Paul, Gulyban Akos, Collette Laurence, Stupp Roger, Weber Damien C., Davis J. Bernard , Aird Edwin, Baumert Brigitta G.
ISSN
1879-0887[electronic], 0167-8140[linking]
Publication state
Published
Issued date
2010
Volume
95
Number
2
Pages
218-224
Language
english
Abstract
PURPOSE: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. MATERIALS AND METHODS: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF x CF); dose homogeneity in PTV (U). RESULTS: Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated > 10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTV(Dmin), improving CF. U correlated with PTV(Dmax). CONCLUSION: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue.
Keywords
Conformal Radiotherapy, Dummy Run, Conformity Indices, Low-Grade Gliomas, Homogeneity, Quality Assurance, Radiation-Therapy, Randomized Trial, European Organization, Cancer-Treatment, Assurance, Oncology, Temozolomide, Prostate
Pubmed
Web of science
Create date
08/06/2010 15:25
Last modification date
20/08/2019 15:00
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