Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: Importance in the control of blood pressure and hypertension.

Détails

Ressource 1Télécharger: 5_23684652_Postprint.pdf (1456.21 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_4C555D266DE6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: Importance in the control of blood pressure and hypertension.
Périodique
Febs Letters
Auteur(s)
Rossier B.C., Staub O., Hummler E.
ISSN
1873-3468 (Electronic)
ISSN-L
0014-5793
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
587
Numéro
13
Pages
1929-1941
Langue
anglais
Notes
Publication types: Journal Article ; pdf : Review
Résumé
In this review, we discuss genetic evidence supporting Guyton's hypothesis stating that blood pressure control is critically depending on fluid handling by the kidney. The review is focused on the genetic dissection of sodium and potassium transport in the distal nephron and the collecting duct that are the most important sites for the control of sodium and potassium balance by aldosterone and angiotensin II. Thanks to the study of Mendelian forms of hypertension and their corresponding transgenic mouse models, three main classes of diuretic receptors (furosemide, thiazide, amiloride) and the main components of the aldosterone- and angiotensin-dependent signaling pathways were molecularly identified over the past 20years. This will allow to design rational strategies for the treatment of hypertension and for the development of the next generation of diuretics.
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/06/2013 10:44
Dernière modification de la notice
20/08/2019 15:00
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