Transforming growth factor beta 1 production by CD4+ CD25+ regulatory T cells in peripheral blood mononuclear cells from healthy subjects stimulated with Leishmania guyanensis.

Détails

ID Serval
serval:BIB_4C31D9618F01
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Transforming growth factor beta 1 production by CD4+ CD25+ regulatory T cells in peripheral blood mononuclear cells from healthy subjects stimulated with Leishmania guyanensis.
Périodique
Infection and Immunity
Auteur(s)
Kariminia A., Bourreau E., Pascalis H., Couppié P., Sainte-Marie D., Tacchini-Cottier F., Launois P.
ISSN
0019-9567 (Print)
ISSN-L
0019-9567
Statut éditorial
Publié
Date de publication
2005
Volume
73
Numéro
9
Pages
5908-5914
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Transforming growth factor beta (TGF-beta) has been shown to be a central immunomodulator used by leishmaniae to escape effective mechanisms of protection in human and murine infections with these parasites. However, all the information is derived from studies of established infection, while little is known about TGF-beta production in response to Leishmania stimulation in healthy subjects. In this study, TGF-beta1 production was demonstrated in peripheral blood mononuclear cells from healthy subjects never exposed to leishmaniae in response to live Leishmania guyanensis, and the TGF-beta1-producing cells were described as a distinct subpopulation of CD4(+) CD25(+) regulatory T cells. The suppressive properties of CD4(+) CD25(+) T cells were demonstrated in vitro by their inhibition of production of interleukin 2 (IL-2) and IL-10 by CD4(+) CD25(-) T cells in the presence of either anti-CD3 or L. guyanensis. Although neutralization of TGF-beta1 did not reverse the suppressive activity of CD4(+) CD25(+) T cells activated by anti-CD3, it reversed the suppressive activity of CD4(+) CD25(+) T cells activated by L. guyanensis. Altogether our data demonstrated that TGF-beta1 is involved in the suppressive activity of L. guyanensis-stimulated CD4(+) CD25(+) T cells from healthy controls.
Mots-clé
Animals, Humans, Interleukin-10/antagonists & inhibitors, Interleukin-10/metabolism, Interleukin-2/antagonists & inhibitors, Interleukin-2/metabolism, Leishmania guyanensis/immunology, Leishmaniasis, Mucocutaneous/immunology, Receptors, Interleukin-2/biosynthesis, Receptors, Interleukin-2/immunology, T-Lymphocytes, Regulatory/immunology, T-Lymphocytes, Regulatory/metabolism, Transforming Growth Factor beta/biosynthesis, Transforming Growth Factor beta/physiology, Transforming Growth Factor beta1
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:08
Dernière modification de la notice
20/08/2019 15:00
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