Article: article from journal or magazin.
Morphological changes of thymus in retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS).
Pathology, Research and Practice
The possible contribution of the thymus in the setting of acquired immunodeficiencies is still questioned. Here we report some new findings regarding a potential involvement of the thymus in mice infected with RadLV-Rs, a viral mixture inducing murine acquired immunodeficiency syndrome (MAIDS). Thymi were sequentially removed, weighted and morphologically analyzed at different time intervals post-infection. Infection with RadLV-Rs led to a decrease in thymus weight mostly apparent from the fourth week. The first changes were seen at the third week as perivascular clusters of B-cells at the cortico-medullary junction. The ensuing process of atrophy mainly involved the cortex, while a mixed population of large T- and B-cells filled the medulla. These observations are discussed with regard to the pathological changes occurring in other lymphoid and non-lymphoid organs, in the context of the lymphoproliferation and immunodeficiency characterizing the disease, and by comparison with other models of retrovirus-induced immunodeficiencies.
Animals, Atrophy/pathology, Disease Models, Animal, Male, Mice, Mice, Inbred C57BL, Murine Acquired Immunodeficiency Syndrome/pathology, Organ Size, Retroviridae, Thymus Gland/pathology, Time Factors
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