Article: article from journal or magazin.
Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.
Proceedings of the National Academy of Sciences of the United States of America
The protease activity of the paracaspase Malt1 contributes to antigen receptor-mediated lymphocyte activation and lymphomagenesis. Malt1 activity is required for optimal NF-κB activation, but little is known about the responsible substrate(s). Here we report that Malt1 cleaved the NF-κB family member RelB after Arg-85. RelB cleavage induced its proteasomal degradation and specifically controlled DNA binding of RelA- or c-Rel-containing NF-κB complexes. Overexpression of RelB inhibited expression of canonical NF-κB target genes and led to impaired survival of diffuse large B-cell lymphoma cell lines characterized by constitutive Malt1 activity. These findings identify a central role for Malt1-dependent RelB cleavage in canonical NF-κB activation and thereby provide a rationale for the targeting of Malt1 in immunomodulation and cancer treatment.
Caspases/physiology, Cell Line, Tumor, Humans, Lymphocyte Activation, Lymphocytes/metabolism, Lymphoma, Large B-Cell, Diffuse/etiology, Lymphoma, Large B-Cell, Diffuse/metabolism, NF-kappa B/metabolism, Neoplasm Proteins/physiology, Transcription Factor RelA/metabolism, Transcription Factor RelB/metabolism
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