Metabolic dynamics instruct CD8<sup>+</sup> T-cell differentiation and functions.

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_4B5AE6597A0A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Metabolic dynamics instruct CD8<sup>+</sup> T-cell differentiation and functions.
Journal
European journal of immunology
Author(s)
Bevilacqua A., Li Z., Ho P.C.
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Publication state
Published
Issued date
04/2022
Peer-reviewed
Oui
Volume
52
Number
4
Pages
541-549
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Cytotoxic CD8 <sup>+</sup> T cells are a key element of the adaptative immune system to protect the organism against infections and malignant cells. During their activation and response, T cells undergo different metabolic pathways to support their energetic needs according to their localization and function. However, it has also been recently appreciated that this metabolic reprogramming also directly supports T-cell lineage differentiation. Accordingly, metabolic deficiencies and prolonged stress exposure can impact T-cell differentiation and skew them into an exhausted state. Here, we review how metabolism defines CD8 <sup>+</sup> T-cell differentiation and function. Moreover, we cover the principal metabolic dysregulation that promotes the exhausted phenotype under tumor or chronic virus conditions. Finally, we summarize recent strategies to reprogram impaired metabolic pathways to promote CD8 <sup>+</sup> T-cell effector function and survival.
Keywords
CD8-Positive T-Lymphocytes, Cell Differentiation, Lymphocyte Activation, Lymphocyte Count, T-Lymphocytes, Cytotoxic, T-cell differentiation, T-cell exhaustion, T cells, infection, metabolism
Pubmed
Web of science
Open Access
Yes
Create date
14/03/2022 8:45
Last modification date
23/11/2022 7:10
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