Sex differences in neurodevelopmental and common mental disorders examined from three epidemiological perspectives.

Détails

Ressource 1Demande d'une copie Sous embargo jusqu'au 14/06/2020.
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_4B2D8931709E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sex differences in neurodevelopmental and common mental disorders examined from three epidemiological perspectives.
Périodique
Psychiatry research
Auteur(s)
Tesic A., Rodgers S., Müller M., Wagner E.N., von Känel R., Castelao E., Strippoli M.F., Vandeleur C.L., Seifritz E., Preisig M., Ajdacic-Gross V.
ISSN
1872-7123 (Electronic)
ISSN-L
0165-1781
Statut éditorial
Publié
Date de publication
08/2019
Peer-reviewed
Oui
Volume
278
Pages
213-217
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Sex differences in neurodevelopmental and common mental disorders are a ubiquitous, well-known, though poorly understood phenomenon. This study examined the issue from three epidemiological perspectives: congruence in age of onset, distribution of sex-ratios with respect to age of onset and similarity of comorbidity and risk factor patterns. The analysis was based on data from the population-based PsyCoLaus study (N = 4874, age 35-82 y). Congruence in age of onset and distribution of sex-ratios were examined with the Mann-Whitney test and cluster analysis. The similarity of comorbidity and risk factor patterns, which were represented by 35 variables, was assessed with the Jaccard coefficient and, after factor analysis, with Tucker's congruence coefficient. While age of onset parameters differed little by sex, the sex ratio varied markedly both in early and in late onset disorders. Moreover, the Jaccard coefficients for most disorders indicated that the similarity of comorbidity and further association patterns was low. Similarly, Tucker's congruence coefficient remained below the range of fair similarity in all factor combinations. In sum, sex differences in common mental disorders were impressively reflected by diverging sex ratios and comorbidity / risk factor patterns. This outcome supports the notion that most mental disorders need a sex-specific etiopathogenetic understanding.
Mots-clé
Age of onset, Mental disorders, Neurodevelopmental disorders, Sex differences, Sex ratio, Similarity index
Pubmed
Web of science
Création de la notice
25/06/2019 10:08
Dernière modification de la notice
27/09/2019 8:48
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