Hypertension differentially affects the expression of the gap junction protein connexin43 in cardiac myocytes and aortic smooth muscle cells.

Détails

ID Serval
serval:BIB_4B1F6D7E371D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hypertension differentially affects the expression of the gap junction protein connexin43 in cardiac myocytes and aortic smooth muscle cells.
Périodique
Advances in experimental medicine and biology
Auteur(s)
Haefliger J.A., Castillo E., Waeber G., Aubert J.F., Nicod P., Waeber B., Meda P.
ISSN
0065-2598
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
432
Pages
71-82
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Electrical and mechanical coupling of myocytes in heart and of smooth muscle cells in the aortic wall is thought to be mediated by intercellular channels aggregated at gap junctions. Connexin43 (Cx43) is one of the predominant membrane proteins forming junctional channels in the cardiovascular system. This study was undertaken to assess its expression during experimental hypertension. Rats were made hypertensive by clipping one renal artery (two-kidney, one-clip renal hypertension) or by administering deoxycorticosterone and salt (DOCA-salt hypertension). After four weeks, rats from both models showed a similar increase in intra-arterial mean blood pressure, as well as in the thickness of both aorta and heart walls. Northern blot analysis showed that, compared to controls, hypertensive rats expressed twice more Cx43 in aorta, but not in heart. These results suggest that localized mechanical forces induced by hypertension are major tissue-specific regulators of Cx43 expression.
Mots-clé
Animals, Aorta, Blood Pressure, Connexin 43, Desoxycorticosterone, Hypertension, Hypertension, Renovascular, Muscle, Smooth, Vascular, Myocardium, Rats, Sodium, Dietary
Pubmed
Web of science
Création de la notice
17/11/2008 9:57
Dernière modification de la notice
20/08/2019 14:58
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