Local Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor.

Détails

Ressource 1Télécharger: BIB_4AEADA8DF103.P001.pdf (919.89 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_4AEADA8DF103
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Local Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor.
Périodique
Oncoimmunology
Auteur(s)
Domingos-Pereira S., Hojeij R., Reggi E., Derré L., Chevalier M.F., Romero P., Jichlinski P., Nardelli-Haefliger D.
ISSN
2162-4011 (Print)
ISSN-L
2162-4011
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
4
Numéro
7
Pages
e1016697
Langue
anglais
Notes
Publication types: ARTICLEPublication Status: epublish
Résumé
The efficacy of antitumoral responses can be increased using combinatorial vaccine strategies. We recently showed that vaccination could be optimized by local administration of diverse molecular or bacterial agents to target and augment antitumoral CD8 T cells in the genital mucosa (GM) and increase regression of cervical cancer in an animal model. Non muscle-invasive bladder cancer is another disease that is easily amenable to local therapies. In contrast to data obtained in the GM, in this study we show that intravesical (IVES) instillation of synthetic toll-like receptor (TLR) agonists only modestly induced recruitment of CD8 T cells to the bladder. However, IVES administration of Ty21a, a live bacterial vaccine against typhoid fever, was much more effective and increased the number of total and vaccine-specific CD8 T cells in the bladder approximately 10 fold. Comparison of chemokines induced in the bladder by either CpG (a TLR-9 agonist) or Ty21a highlighted the preferential increase in complement component 5a, CXCL5, CXCL2, CCL8, and CCL5 by Ty21a, suggesting their involvement in the attraction of T cells to the bladder. IVES treatment with Ty21a after vaccination also significantly increased tumor regression compared to vaccination alone, resulting in 90% survival in an orthotopic murine model of bladder cancer expressing a prototype tumor antigen. Our data demonstrate that combining vaccination with local immunostimulation may be an effective treatment strategy for different types of cancer and also highlight the great potential of the Ty21a vaccine, which is routinely used worldwide, in such combinatorial therapies.
Pubmed
Web of science
Création de la notice
20/07/2015 11:29
Dernière modification de la notice
03/03/2018 16:57
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