Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage.

Détails

ID Serval
serval:BIB_4AE452F6077F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage.
Périodique
Blood
Auteur(s)
Ferrero I., Held W., Wilson A., Tacchini-Cottier F., Radtke F., MacDonald H.R.
ISSN
0006-4971
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
100
Numéro
8
Pages
2852-2857
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The developmental origin of dendritic cells (DCs) is controversial. In the mouse CD8alpha(+) and CD8alpha(-) DC subsets are often considered to be of lymphoid and myeloid origin respectively, although evidence on this point is conflicting. Very recently a novel CD11c(+) B220(+) DC subset has been identified that appears to be the murine counterpart to interferon alpha (IFNalpha)-producing human plasmacytoid DCs (PDCs). We show here that CD11c(+) B220(+) mouse PDCs, like human PDCs, are present in the thymus and express T lineage markers such as CD8alpha and CD4. However, the intrathymic development of PDCs can be completely dissociated from immature T lineage cells in mixed chimeras established with bone marrow cells from mice deficient for either Notch-1 or T-cell factor 1, two independent mutations that severely block early T-cell development. Our data indicate that thymic PDCs do not arise from a bipotential T/DC precursor.
Mots-clé
Animals, Antigens, CD11c/blood, Antigens, CD45/blood, Bone Marrow Cells/cytology, Bone Marrow Cells/physiology, Chimera/immunology, Dendritic Cells/immunology, Humans, Mice, Mice, Inbred C57BL, Models, Animal, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:39
Dernière modification de la notice
20/08/2019 14:58
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