Magnetic resonance myocardial first-pass perfusion imaging: parameter optimization for signal response and cardiac coverage.

Détails

ID Serval
serval:BIB_4AE3F832D9C0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Magnetic resonance myocardial first-pass perfusion imaging: parameter optimization for signal response and cardiac coverage.
Périodique
Journal of Magnetic Resonance Imaging
Auteur(s)
Bertschinger K.M., Nanz D., Buechi M., Luescher T.F., Marincek B., von Schulthess G.K., Schwitter J.
ISSN
1053-1807 (Print)
ISSN-L
1053-1807
Statut éditorial
Publié
Date de publication
2001
Volume
14
Numéro
5
Pages
556-562
Langue
anglais
Résumé
Fast imaging techniques allow monitoring of contrast medium (CM) first-pass kinetics in a multislice mode. Employing shorter recovery times improves cardiac coverage during first-pass conditions, but potentially flattens signal response in the myocardium. The aim of this study was therefore to compare in patients with suspected coronary artery disease (CAD) two echo-planar imaging strategies yielding either extended cardiac coverage or optimized myocardial signal response (protocol A/B, six/four slices; preparation pulse, 60 degrees /90 degrees; delay time, 10/120 msec; readout flip angle, 10 degrees /50 degrees; respectively). In phantoms and myocardium of normal volunteers (N= 10) the CM-induced signal increase was 2.5-3 times higher with protocol B (P < 0.005) than with protocol A. For the detection of individually diseased coronary arteries (> or =1 stenosis with > or =50% diameter reduction on quantitative coronary angiography (QCA)), receiver-operator characteristics of protocol B (signal upslope in 32 sectors/heart) yielded a sensitivity/specificity of 82%/73%, which was superior to protocol A (P < 0.05, N= 14). For the overall detection of CAD, the sensitivity/specificity of protocol B was 85%/81%. An adequate signal response in the myocardium is crucial for a reliable detection of perfusion deficits during first-pass conditions. The presented protocol B detects CAD with a sensitivity and specificity similar to scintigraphic techniques.
Mots-clé
Coronary Disease/diagnosis, Echo-Planar Imaging/methods, Heart/anatomy & histology, Humans, Myocardium/pathology, Phantoms, Imaging, ROC Curve, Sensitivity and Specificity, Signal Processing, Computer-Assisted
Pubmed
Web of science
Création de la notice
07/09/2011 18:50
Dernière modification de la notice
20/08/2019 14:58
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