Strategies for overcoming tumour resistance to immunotherapy: harnessing the power of radiation therapy.
Details
Serval ID
serval:BIB_4AE24FD1B1B0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Strategies for overcoming tumour resistance to immunotherapy: harnessing the power of radiation therapy.
Journal
The British journal of radiology
ISSN
1748-880X (Electronic)
ISSN-L
0007-1285
Publication state
Published
Issued date
01/08/2024
Peer-reviewed
Oui
Volume
97
Number
1160
Pages
1378-1390
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment; yet their efficacy remains variable across patients. This review delves into the intricate interplay of tumour characteristics contributing to resistance against ICI therapy and suggests that combining with radiotherapy holds promise. Radiation, known for its ability to trigger immunogenic cell death and foster an in situ vaccination effect, may counteract these resistance mechanisms, enhancing ICI response and patient outcomes. However, particularly when delivered at high-dose, it may trigger immunosuppressive mechanism and consequent side-effects. Notably, low-dose radiotherapy (LDRT), with its capacity for tumour reprogramming and reduced side effects, offers the potential for widespread application. Preclinical and clinical studies have shown encouraging results in this regard.
Keywords
Humans, Neoplasms/radiotherapy, Neoplasms/immunology, Neoplasms/therapy, Immune Checkpoint Inhibitors/therapeutic use, Immune Checkpoint Inhibitors/pharmacology, Immunotherapy/methods, Drug Resistance, Neoplasm, Radiotherapy Dosage, abscopal, immunotherapy, low dose radiation, radiation oncology, radiotherapy
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2024 14:58
Last modification date
27/07/2024 6:00