Protein-protein interactions at the adrenergic receptors.

Détails

Ressource 1Télécharger: BIB_4AB2C5B53D6D.P001.pdf (635.49 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_4AB2C5B53D6D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Protein-protein interactions at the adrenergic receptors.
Périodique
Current Drug Targets
Auteur(s)
Cotecchia S., Stanasila L., Diviani D.
ISSN
1873-5592 (Electronic)
ISSN-L
1389-4501
Statut éditorial
Publié
Date de publication
2012
Volume
13
Numéro
1
Pages
15-27
Langue
anglais
Résumé
The adrenergic receptors are among the best characterized G protein-coupled receptors (GPCRs) and knowledge on this receptor family has provided several important paradigms about GPCR function and regulation. One of the most recent paradigms initially supported by studies on adrenergic receptors is that both βarrestins and G proteincoupled receptors themselves can act as scaffolds binding a variety of proteins and this can result in growing complexity of the receptor-mediated cellular effects. In this review we will briefly summarize the main features of βarrestin binding to the adrenergic receptor subtypes and we will review more in detail the main proteins found to selectively interact with distinct AR subtype. At the end, we will review the main findings on oligomerization of the AR subtypes.
Mots-clé
Adrenergic receptor subtypes, signaling complexes, arrestins, receptor oligomerization
Pubmed
Web of science
Création de la notice
15/02/2012 11:49
Dernière modification de la notice
20/08/2019 13:58
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