The required beta cell research for improving treatment of type 2 diabetes.

Details

Serval ID
serval:BIB_4A66DC9B3E91
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The required beta cell research for improving treatment of type 2 diabetes.
Journal
Journal of Internal Medicine
Author(s)
Thorens B.
ISSN
1365-2796 (Electronic)
ISSN-L
0954-6820
Publication state
Published
Issued date
2013
Volume
274
Number
3
Pages
203-214
Language
english
Abstract
In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hyperglycaemia. Incomplete understanding of the molecular mechanisms controlling the plasticity of adult beta cells mechanisms and how these cells fail during the pathogenesis of diabetes strongly limits the ability to develop new beta cell-specific therapies. Here, current knowledge of the signalling pathways controlling beta cell plasticity is reviewed, and possible directions for future research are discussed.
Keywords
apoptosis, beta cells, diabetes, GLP-1, insulin secretion, pregnancy
Pubmed
Web of science
Open Access
Yes
Create date
05/09/2013 12:58
Last modification date
20/08/2019 13:58
Usage data