The required beta cell research for improving treatment of type 2 diabetes.

Détails

ID Serval
serval:BIB_4A66DC9B3E91
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The required beta cell research for improving treatment of type 2 diabetes.
Périodique
Journal of Internal Medicine
Auteur(s)
Thorens B.
ISSN
1365-2796 (Electronic)
ISSN-L
0954-6820
Statut éditorial
Publié
Date de publication
2013
Volume
274
Numéro
3
Pages
203-214
Langue
anglais
Résumé
In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hyperglycaemia. Incomplete understanding of the molecular mechanisms controlling the plasticity of adult beta cells mechanisms and how these cells fail during the pathogenesis of diabetes strongly limits the ability to develop new beta cell-specific therapies. Here, current knowledge of the signalling pathways controlling beta cell plasticity is reviewed, and possible directions for future research are discussed.
Mots-clé
apoptosis, beta cells, diabetes, GLP-1, insulin secretion, pregnancy
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/09/2013 12:58
Dernière modification de la notice
20/08/2019 13:58
Données d'usage