In vivo induction of pyrimidine dimers in human skin by UVA radiation: initiation of cell damage and/or intercellular communication?

Détails

ID Serval
serval:BIB_4A097F882D6E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
In vivo induction of pyrimidine dimers in human skin by UVA radiation: initiation of cell damage and/or intercellular communication?
Périodique
International Journal of Molecular Medicine
Auteur(s)
Applegate  L. A., Scaletta  C., Panizzon  R., Niggli  H., Frenk  E.
ISSN
1107-3756 (Print)
Statut éditorial
Publié
Date de publication
05/1999
Volume
3
Numéro
5
Pages
467-72
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
Pyrimidine dimers participate as important factors in ultraviolet-induced lethality, mutagenicity and tumorgenicity. Substantial efforts have been made in recent years to understand the induction of pyrimidine photodimers and their repair in human skin cells exposed to low physiological fluences of UV-light. Dimers are known to be efficiently induced after UVC and UVB irradiation, but these photoproducts are also highly induced in DNA isolated from human skin irradiated with UVA. By using a sensitive immunohistochemistry dimer detection assay, we confirm that in vivo UVA radiation induces substantial amounts of these DNA changes in the epidermis; in addition, this technique detects them far into the reticular dermis. A considerable number of these photodimers were also seen in non-irradiated control skin up to two centimeters from the irradiation site. All the lesions persist for at least two days post-irradiation. These results sustain the hypothesis that pyrimidine dimer formation and excision could be a modality of epidermal communication.
Mots-clé
Adult Case-Control Studies Cell Communication/radiation effects DNA Damage DNA Repair Female Humans Immunohistochemistry Male Models, Biological Pyrimidine Dimers/analysis/*biosynthesis/*radiation effects Skin/injuries/*metabolism/*radiation effects Ultraviolet Rays/adverse effects
Pubmed
Web of science
Création de la notice
25/01/2008 16:54
Dernière modification de la notice
20/08/2019 13:57
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