Determinants for membrane association of the hepatitis C virus NS2 protease domain.

Détails

ID Serval
serval:BIB_49965DC01ED0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Determinants for membrane association of the hepatitis C virus NS2 protease domain.
Périodique
Journal of Virology
Auteur(s)
Lange C.M., Bellecave P., Dao Thi V.L., Tran H.T., Penin F., Moradpour D., Gouttenoire J.
ISSN
1098-5514 (Electronic)
ISSN-L
0022-538X
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
88
Numéro
11
Pages
6519-6523
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Résumé
Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is required for HCV polyprotein processing and particle assembly. It comprises an N-terminal membrane domain and a C-terminal, cytosolically oriented protease domain. Here, we demonstrate that the NS2 protease domain itself associates with cellular membranes. A single charged residue in the second α-helix of the NS2 protease domain is required for proper membrane association, NS2 protein stability, and efficient HCV polyprotein processing.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/06/2014 15:08
Dernière modification de la notice
20/08/2019 14:57
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