Could concomitant radio-chemotherapy improve the outcomes of early-stage node negative anal canal cancer patients? A retrospective analysis of 122 patients.

Détails

ID Serval
serval:BIB_498D80BD8F46
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Could concomitant radio-chemotherapy improve the outcomes of early-stage node negative anal canal cancer patients? A retrospective analysis of 122 patients.
Périodique
Cancer Investigation
Auteur(s)
De Bari B., Lestrade L., Pommier P., Maddalo M., Buglione M., Magrini S.M., Carrie C.
ISSN
1532-4192 (Electronic)
ISSN-L
0735-7907
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
33
Numéro
4
Pages
114-120
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
One hundred twenty-two early-stage anal canal cancer patients (median age: 69 years) were treated with curative radiotherapy with (70 patients) or without (52 patients) concomitant chemotherapy. Median follow-up was 65 months (range: 4-238). At multivariate analysis, concomitant chemotherapy significantly improved local control (p = .007). Local control significantly influenced all considered endpoints, except the metastases free survival. The global rates of G3-G4 acute and late toxicity were 13.1% and 8.2%, respectively, and they were not increased by concomitant chemotherapy. Finally, concomitant chemotherapy is efficacious and safe in the treatment of T1-2N0 anal canal cancer patients and should be prospectively studied.
Pubmed
Web of science
Création de la notice
22/05/2015 18:07
Dernière modification de la notice
20/08/2019 13:56
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