MorphoGraphX: A platform for quantifying morphogenesis in 4D.

Détails

ID Serval
serval:BIB_496F1EEE867E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MorphoGraphX: A platform for quantifying morphogenesis in 4D.
Périodique
Elife
Auteur(s)
Barbier de Reuille P., Routier-Kierzkowska A.L., Kierzkowski D., Bassel G.W., Schüpbach T., Tauriello G., Bajpai N., Strauss S., Weber A., Kiss A., Burian A., Hofhuis H., Sapala A., Lipowczan M., Heimlicher M.B., Robinson S., Bayer E.M., Basler K., Koumoutsakos P., Roeder A.H., Aegerter-Wilmsen T., Nakayama N., Tsiantis M., Hay A., Kwiatkowska D., Xenarios I., Kuhlemeier C., Smith R.S.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Statut éditorial
Publié
Date de publication
2015
Volume
4
Pages
05864
Langue
anglais
Résumé
Morphogenesis emerges from complex multiscale interactions between genetic and mechanical processes. To understand these processes, the evolution of cell shape, proliferation and gene expression must be quantified. This quantification is usually performed either in full 3D, which is computationally expensive and technically challenging, or on 2D planar projections, which introduces geometrical artifacts on highly curved organs. Here we present MorphoGraphX ( www.MorphoGraphX.org), a software that bridges this gap by working directly with curved surface images extracted from 3D data. In addition to traditional 3D image analysis, we have developed algorithms to operate on curved surfaces, such as cell segmentation, lineage tracking and fluorescence signal quantification. The software's modular design makes it easy to include existing libraries, or to implement new algorithms. Cell geometries extracted with MorphoGraphX can be exported and used as templates for simulation models, providing a powerful platform to investigate the interactions between shape, genes and growth.
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/05/2015 20:42
Dernière modification de la notice
20/08/2019 13:56
Données d'usage