Effects of the peroxisomal proliferator-activated receptor-gamma agonist pioglitazone on renal and hormonal responses to salt in healthy men.

Details

Serval ID
serval:BIB_48EF40A166F5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of the peroxisomal proliferator-activated receptor-gamma agonist pioglitazone on renal and hormonal responses to salt in healthy men.
Journal
Journal of Clinical Endocrinology and Metabolism
Author(s)
Zanchi A., Chiolero A., Maillard M., Nussberger J., Brunner H.R., Burnier M.
ISSN
0021-972X
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
89
Number
3
Pages
1140-1145
Language
english
Notes
Publication types: Clinical Trial ; Journal Article
Abstract
Glitazones are used in the treatment of type 2 diabetes as efficient insulin sensitizers. They can, however, induce peripheral edema through an unknown mechanism in up to 18% of cases. In this double-blind, randomized, placebo-controlled, four-way, cross-over study, we examined the effects of a 6-wk administration of pioglitazone (45 mg daily) or placebo on the blood pressure, hormonal, and renal hemodynamic and tubular responses to a low (LS) and a high (HS) sodium diet in healthy volunteers. Pioglitazone had no effect on the systemic and renal hemodynamic responses to salt, except for an increase in daytime heart rate. Urinary sodium excretion and lithium clearance were lower with pioglitazone, particularly with the LS diet (P < 0.05), suggesting increased sodium reabsorption at the proximal tubule. Pioglitazone significantly increased plasma renin activity with the LS (P = 0.02) and HS (P = 0.03) diets. Similar trends were observed with aldosterone. Atrial natriuretic levels did not change with pioglitazone. Body weight increased with pioglitazone in most subjects. Pioglitazone stimulates plasma renin activity and favors sodium retention and weight gain in healthy volunteers. These effects could contribute to the development of edema in some subjects treated with glitazones.
Keywords
Adult, Aldosterone, Atrial Natriuretic Factor, Blood Pressure, Cross-Over Studies, Diet, Sodium-Restricted, Humans, Hypoglycemic Agents, Male, Placebos, Receptors, Cytoplasmic and Nuclear, Renal Circulation, Renin, Sodium Chloride, Thiazolidinediones, Transcription Factors
Pubmed
Web of science
Open Access
Yes
Create date
11/02/2008 9:30
Last modification date
20/08/2019 13:56
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