Peri-personal space encoding in patients with disorders of consciousness and cognitive-motor dissociation.

Détails

ID Serval
serval:BIB_48D662A4017F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Peri-personal space encoding in patients with disorders of consciousness and cognitive-motor dissociation.
Périodique
NeuroImage. Clinical
Auteur(s)
Noel J.P., Chatelle C., Perdikis S., Jöhr J., Lopes Da Silva M., Ryvlin P., De Lucia M., Millán JDR, Diserens K., Serino A.
ISSN
2213-1582 (Electronic)
ISSN-L
2213-1582
Statut éditorial
In Press
Peer-reviewed
Oui
Volume
24
Pages
101940
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Résumé
Behavioral assessments of consciousness based on overt command following cannot differentiate patients with disorders of consciousness (DOC) from those who demonstrate a dissociation between intent/awareness and motor capacity: cognitive motor dissociation (CMD). We argue that delineation of peri-personal space (PPS) - the multisensory-motor space immediately surrounding the body - may differentiate these patients due to its central role in mediating human-environment interactions, and putatively in scaffolding a minimal form of selfhood. In Experiment 1, we determined a normative physiological index of PPS by recording electrophysiological (EEG) responses to tactile, auditory, or audio-tactile stimulation at different distances (5 vs. 75 cm) in healthy volunteers (N = 19). Contrasts between paired (AT) and summed (A + T) responses demonstrated multisensory supra-additivity when AT stimuli were presented near, i.e., within the PPS, and highlighted somatosensory-motor sensors as electrodes of interest. In Experiment 2, we recorded EEG in patients behaviorally diagnosed as DOC or putative CMD (N = 17, 30 sessions). The PPS-measure developed in Experiment 1 was analyzed in relation with both standard clinical diagnosis (i.e., Coma Recovery Scale; CRS-R) and a measure of neural complexity associated with consciousness. Results demonstrated a significant correlation between the PPS measure and neural complexity, but not with the CRS-R, highlighting the added value of the physiological recordings. Further, multisensory processing in PPS was preserved in putative CMD but not in DOC patients. Together, the findings suggest that indexing PPS allows differentiating between groups of patients whom both show overt motor impairments (DOC and CMD) but putatively distinct levels of awareness or motor intent.
Mots-clé
Brain injury, Disorders of consciousness, Electroencephalography, Motor-cognitive dissociation, Multisensory, Peri-personal space
Pubmed
Open Access
Oui
Création de la notice
06/08/2019 17:24
Dernière modification de la notice
21/08/2019 6:33
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