Prediction of sustained antihypertensive efficacy of chronic captopril therapy: relationships to immediate blood pressure response and control plasma renin activity

Details

Serval ID
serval:BIB_481FA647F266
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prediction of sustained antihypertensive efficacy of chronic captopril therapy: relationships to immediate blood pressure response and control plasma renin activity
Journal
American Heart Journal
Author(s)
Waeber B., Gavras I., Brunner  H. R., Cook  C. A., Charocopos F., Gavras  H. P.
ISSN
0002-8703
Publication state
Published
Issued date
1982
Peer-reviewed
Oui
Volume
103
Number
3
Pages
384-90
Language
english
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Abstract
The blood pressure (BP) lowering effect of the orally active angiotensin converting enzyme inhibitor, captopril (SQ14225), was studied in 59 hypertensive patients maintained on a constant sodium intake. Within 2 hours of the first dose of captopril BP fell from 171/107 to a maximum low of 142/92 mm Hg (p less than 0.001), and after 4 to 8 days to treatment BP averaged 145/94 mm Hg (p less than 0.001). The magnitude of BP drop induced by captopril was significantly correlated to baseline plasma renin activity (PRA) both during the acute phase (r = -0.38, p less than 0.01) and after the 4 to 8-day interval (r = -0.33, p less than 0.01). Because of considerable scatter in individual data, renin profiling was not precisely predictive of the immediate or delayed BP response of separate patients. However, the BP levels achieved following the initial dose of captopril were closely correlated to BP measured after 4 to 8 days of therapy, and appeared to have greater predictive value than control PRA of the long-term efficacy of chronic captopril therapy despite marked BP changes occurring in some patients during the intermediate period. Because of these intermediate BP changes, addition of a diuretic to enhance antihypertensive effectiveness of angiotensin blockade should be restrained for several days after initiation of captopril therapy.
Keywords
AdultAgedAldosterone/bloodAngiotensin-Converting Enzyme InhibitorsAntihypertensive Agents/therapeutic useBlood Pressure/*drug effectsCaptopril/*therapeutic useCreatinine/bloodDose-Response Relationship, DrugFemaleHumansHypertension/*drug therapyHypertension, Renovascular/drug therapyKidney Failure, Chronic/drug therapyMaleMiddle AgedProline/*analogs & derivativesRenin/*bloodTime Factors
Pubmed
Web of science
Create date
04/03/2009 15:05
Last modification date
20/08/2019 13:54
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