The prominent role of neutrophils during the initial phase of infection by Leishmania parasites.

Détails

Ressource 1Télécharger: BIB_4817EECC488D.P001.pdf (194.17 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_4817EECC488D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The prominent role of neutrophils during the initial phase of infection by Leishmania parasites.
Périodique
Journal of Biomedicine and Biotechnology
Auteur(s)
Charmoy M., Auderset F., Allenbach C., Tacchini-Cottier F.
ISSN
1110-7251
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
2010
Pages
719361
Langue
anglais
Résumé
Neutrophils are rapidly and massively recruited to the site of Leishmania inoculation, where they phagocytose the parasites, some of which are able to survive within these first host cells. Neutrophils can thus provide a transient safe shelter for the parasites, prior to their entry into macrophages where they will replicate. In addition, neutrophils release and synthesize rapidly several factors including cytokines and chemokines. The mechanism involved in their rapid recruitment to the site of parasite inoculation, as well as the putative consequences of their massive presence on the microenvironment of the focus of infection will be discussed in the context of the development of the Leishmania-specific immune response.
Mots-clé
TNF RECEPTOR P55, MAJOR INFECTION, CUTANEOUS LEISHMANIASIS, INTRACELLULAR PATHOGENS, MICE LACKING, IN-VIVO, GRANULOCYTES, RESISTANT, CELLS, MACROPHAGES
Pubmed
Création de la notice
16/11/2009 16:00
Dernière modification de la notice
20/08/2019 14:54
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