Position of fixed-dose combinations containing an AT(1)-receptor blocker and a thiazide diuretic.

Détails

ID Serval
serval:BIB_4801300BC11F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Position of fixed-dose combinations containing an AT(1)-receptor blocker and a thiazide diuretic.
Périodique
Blood Pressure
Auteur(s)
Waeber B.
ISSN
0803-7051
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
14
Numéro
6
Pages
324-336
Langue
anglais
Résumé
Treatment of hypertension remains a difficult task despite the availability of different types of medications lowering blood pressure by different mechanisms. In order to reach the target blood pressures recommended today combination therapy is required in most patients. The co-administration of two drugs with different impacts on the cardiovascular system markedly increases the antihypertensive effectiveness without altering adversely tolerability. Fixed low-dose combinations are becoming a valuable option not only as second-line, but also as first-line therapy. In this respect the co-administration of thiazide diuretic with an AT(1)-receptor blocker is particularly appealing. The diuretic-induced decrease in total body sodium activates the renin-angiotensin system, thus rendering blood pressure maintenance angiotensin II-dependent. During blockade of the renin-angiotensin system low doses of thiazides generally suffice, allowing the prevention of undesirable metabolic effects. Also, blockade of the AT(1)-receptor, particularly when angiotensin II production is enhanced in response to diuretic therapy, is expected to be beneficial, since angiotensin II seems to contribute importantly to the pathogenesis of cardiovascular and renal complications of hypertension.
Mots-clé
Angiotensin II Type 1 Receptor Blockers, Drug Therapy, Combination, Humans, Hypertension, Randomized Controlled Trials as Topic, Sodium Chloride Symporter Inhibitors
Pubmed
Web of science
Création de la notice
06/03/2009 13:01
Dernière modification de la notice
03/03/2018 16:51
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