The ubiquitin-proteasome system and signal transduction pathways regulating Epithelial Mesenchymal transition of cancer.

Détails

Ressource 1Télécharger: 22827778_BIB_47FB7265B214.pdf (960.62 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_47FB7265B214
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The ubiquitin-proteasome system and signal transduction pathways regulating Epithelial Mesenchymal transition of cancer.
Périodique
Journal of Biomedical Science
Auteur(s)
Voutsadakis I.A.
ISSN
1423-0127 (Electronic)
ISSN-L
1021-7770
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
19
Pages
67
Langue
anglais
Notes
Publication types: Journal Article
WOS Document Type: Review
Résumé
Epithelial to Mesenchymal transition (EMT) in cancer, a process permitting cancer cells to become mobile and metastatic, has a signaling hardwire forged from development. Multiple signaling pathways that regulate carcinogenesis enabling characteristics in neoplastic cells such as proliferation, resistance to apoptosis and angiogenesis are also the main players in EMT. These pathways, as almost all cellular processes, are in their turn regulated by ubiquitination and the Ubiquitin-Proteasome System (UPS). Ubiquitination is the covalent link of target proteins with the small protein ubiquitin and serves as a signal to target protein degradation by the proteasome or to other outcomes such as endocytosis, degradation by the lysosome or specification of cellular localization. This paper reviews signal transduction pathways regulating EMT and being regulated by ubiquitination.
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/09/2012 19:21
Dernière modification de la notice
08/05/2019 18:02
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