Large-scale analysis of orthologs and paralogs under covarion-like and constant-but-different models of amino acid evolution.

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_47EE94487936
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Large-scale analysis of orthologs and paralogs under covarion-like and constant-but-different models of amino acid evolution.
Périodique
Molecular Biology and Evolution
Auteur(s)
Studer R.A., Robinson-Rechavi M.
ISSN
1537-1719[electronic], 0737-4038[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
27
Numéro
11
Pages
2618-2627
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Functional divergence between homologous proteins is expected to affect amino acid sequences in two main ways, which can be considered as proxies of biochemical divergence: a "covarion-like" pattern of correlated changes in evolutionary rates, and switches in conserved residues ("conserved but different"). Although these patterns have been used in case studies, a large-scale analysis is needed to estimate their frequency and distribution. We use a phylogenomic framework of animal genes to answer three questions: 1) What is the prevalence of such patterns? 2) Can we link such patterns at the amino acid level with selection inferred at the codon level? 3) Are patterns different between paralogs and orthologs? We find that covarion-like patterns are more frequently detected than "constant but different," but that only the latter are correlated with signal for positive selection. Finally, there is no obvious difference in patterns between orthologs and paralogs.
Mots-clé
covarion, positive selection, whole-genome duplication, vertebrate evolution, rate shift, heterotachy
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/06/2010 8:34
Dernière modification de la notice
08/05/2019 18:02
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