Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres

Détails

ID Serval
serval:BIB_47DF33DCE046
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres
Périodique
Vaccine
Auteur(s)
Men  Y., Tamber  H., Audran  R., Gander  B., Corradin  G.
ISSN
0264-410X (Print)
Statut éditorial
Publié
Date de publication
09/1997
Volume
15
Numéro
12-13
Pages
1405-12
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug-Sep
Résumé
We have previously reported that biodegradable polymer microspheres (MS) are capable of eliciting strong and long-lasting antibody and T cell proliferative responses for either natural protein antigens or synthetic peptides. In this study, we investigated the possibility of inducing antigen-specific cytotoxic T lymphocyte (CTL) responses in vivo with a short synthetic peptide from the circumsporozoite (CS) protein of Plasmodium berghei (Pb) 252-260 by using different MS formulations. We show that injection of mice with a short CTL epitope microencapsulated in MS or adsorbed on empty MS enhanced a specific CTL response comparable to that obtained with the incomplete Freund's adjuvant (IFA) formulation, indicating that MS are a potent antigen delivery system/immunostimulant for CTL response. These results might be of practical interest for MS preparation and development of subunit vaccines.
Mots-clé
Animals Antigens, Protozoan/*immunology Biodegradation, Environmental Female Immunization Malaria Vaccines/*immunology Mice Mice, Inbred BALB C Microspheres Protozoan Proteins/administration & dosage/*immunology T-Lymphocytes, Cytotoxic/*immunology
Pubmed
Web of science
Création de la notice
24/01/2008 15:55
Dernière modification de la notice
03/03/2018 16:51
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