Improved Visibility of Metastatic Disease in the Liver During Intra-Arterial Therapy Using Delayed Arterial Phase Cone-Beam CT.

Détails

Ressource 1Télécharger: 270_2016_Article_1406.pdf (770.04 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_47BA4D0B9A0D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Improved Visibility of Metastatic Disease in the Liver During Intra-Arterial Therapy Using Delayed Arterial Phase Cone-Beam CT.
Périodique
Cardiovascular and interventional radiology
Auteur(s)
Schernthaner R.E., Haroun R.R., Duran R., Lee H., Sahu S., Sohn J.H., Chapiro J., Zhao Y., Gorodetski B., Fleckenstein F., Smolka S., Radaelli A., van der Bom I.M., Lin M., Geschwind J.F.
ISSN
1432-086X (Electronic)
ISSN-L
0174-1551
Statut éditorial
Publié
Date de publication
10/2016
Peer-reviewed
Oui
Volume
39
Numéro
10
Pages
1429-1437
Langue
anglais
Notes
Schernthaner, Ruediger E Haroun, Reham R Duran, Rafael Lee, Howard Sahu, Sonia Sohn, Jae Ho Chapiro, Julius Zhao, Yan Gorodetski, Boris Fleckenstein, Florian Smolka, Susanne Radaelli, Alessandro van der Bom, Imramsjah Martijn Lin, MingDe Geschwind, Jean Francois ENG R01 CA160771/CA/NCI NIH HHS/ 2016/07/07 06:00 Cardiovasc Intervent Radiol. 2016 Jul 5.
Publication types: Journal Article
Publication Status: ppublish
Résumé
To compare the visibility of liver metastases on dual-phase cone-beam CT (DP-CBCT) and digital subtraction angiography (DSA), with reference to preinterventional contrast-enhanced magnetic resonance imaging (CE-MRI) of the liver.
This IRB-approved, retrospective study included 28 patients with neuroendocrine (NELM), colorectal (CRCLM), or sarcoma (SLM) liver metastases who underwent DP-CBCT during intra-arterial therapy (IAT) between 01/2010 and 10/2014. DP-CBCT was acquired after a single contrast agent injection in the tumor-feeding arteries at early and delayed arterial phases (EAP and DAP). The visibility of each lesion was graded by two radiologists in consensus on a three-rank scale (complete, partial, none) on DP-CBCT and DSA images using CE-MRI as reference.
47 NELM, 43 CRCLM, and 16 SLM were included. On DSA 85.1, 44.1, and 37.5 % of NELM, CRCLM, and SLM, were at least partially depicted, respectively. EAP-CBCT yielded significantly higher sensitivities of 88.3 and 87.5 % for CRCLM and SLM, respectively (p < 0.01), but not for NELM (89.4 %; p = 1.0). On DAP-CBCT all NELM, CRCLM, and SLM were visible (p < 0.001). Complete depiction was achieved on DSA for 59.6, 16.3, and 18.8 % of NELM, CRCLM, and SLM, respectively. The complete depiction rate on EAP-CBCT was significantly higher for CRCLM (46.5 %; p < 0.001), lower for NELM (40.4 %; p = 0.592), and similar for SLM (25 %, p = 0.399). On DAP-CBCT however, the highest rates of complete depiction were found-NELM (97.8 %; p = 0.008), CRCLM (95.3 %; p = 0.008), and SLM (100 %; p < 0.001).
DAP-CBCT substantially improved the visibility of liver metastases during IAT. Future studies need to evaluate the clinical impact.

Pubmed
Open Access
Oui
Création de la notice
15/08/2016 15:02
Dernière modification de la notice
08/05/2019 18:01
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