Toxoplasma gondii infection during pregnancy: T lymphocyte subpopulations in mothers and fetuses

Détails

ID Serval
serval:BIB_47B8ED2E002E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Toxoplasma gondii infection during pregnancy: T lymphocyte subpopulations in mothers and fetuses
Périodique
Pediatric Infectious Disease Journal
Auteur(s)
Hohlfeld  P., Forestier  F., Marion  S., Thulliez  P., Marcon  P., Daffos  F.
ISSN
0891-3668 (Print)
Statut éditorial
Publié
Date de publication
12/1990
Volume
9
Numéro
12
Pages
878-81
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
Prenatal diagnosis of fetal toxoplasmosis is possible with the use of fetal blood sampling, amniocentesis and ultrasound examination. The purpose of this study was to describe T lymphocyte subsets (CD3, CD4 and CD8) in mothers and their fetuses when Toxoplasma gondii infection occurred during pregnancy. Maternal and fetal blood samples were obtained in 86 cases and 9 fetuses showed T. gondii infection. Control groups consisted of 30 healthy nonpregnant women and 30 pregnant women. Pregnant women with T. gondii infection showed an increase in the suppressor (CD8) T subpopulation and a significant depression in the total helper (CD4) T cells. These alterations were more important in mothers whose fetus was infected. We showed the progressive maturation of the fetal immune system with a regular increase of all T lymphocyte subsets. Marked alterations were observed in the 9 infected fetuses (depression of CD4 population and lower CD4/CD8 ratio). In the future these differences might be used as a new marker of the severity of fetal lesions and become a useful diagnostic tool.
Mots-clé
CD4-Positive T-Lymphocytes Female Fetal Diseases/*blood/diagnosis/immunology Humans Leukocyte Count Pregnancy Pregnancy Complications, Infectious/*blood/diagnosis/immunology *T-Lymphocyte Subsets T-Lymphocytes, Helper-Inducer T-Lymphocytes, Regulatory Toxoplasmosis/*blood/diagnosis/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 12:12
Dernière modification de la notice
20/08/2019 14:54
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