Modified sensory processing in the barrel cortex of the adult mouse after chronic whisker stimulation

Détails

ID Serval
serval:BIB_47A2DF298F58
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Modified sensory processing in the barrel cortex of the adult mouse after chronic whisker stimulation
Périodique
Journal of Neurophysiology
Auteur(s)
Quairiaux  C., Armstrong-James  M., Welker  E.
ISSN
0022-3077 (Print)
Statut éditorial
Publié
Date de publication
03/2007
Volume
97
Numéro
3
Pages
2130-47
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
Chronic stimulation of a mystacial whisker follicle for 24 h induces structural and functional changes in layer IV of the corresponding barrel, with an insertion of new inhibitory synapses on spines and a depression of neuronal responses to the stimulated whisker. Under urethane anesthesia, we analyzed how sensory responses of single units are affected in layer IV and layers II & III of the stimulated barrel column as well as in adjacent columns. In the stimulated column, spatiotemporal characteristics of the activation evoked by the stimulated whisker are not altered, although spontaneous activity and response magnitude to the stimulated whisker are decreased. The sensitivity of neurons for the deflection of this whisker is not altered but the dynamic range of the response is reduced as tested by varying the amplitude and repetition rate of the deflection. Responses to deflection of nonstimulated whiskers remain unaltered with the exception of in-row whisker responses that are depressed in the column corresponding to the stimulated whisker. In adjacent nonstimulated columns, neuronal activity remains unaltered except for a diminished response of units in layer II/III to deflection of the stimulated whisker. From these results we propose that an increased inhibition within the stimulated barrel reduced the magnitude of its excitatory output and accordingly the flow of excitation toward layers II & III and the subsequent spread into adjacent columns. In addition, the period of uncorrelated activity between pathways from the stimulated and nonstimulated whiskers weakens synaptic inputs from in-row whiskers in the stimulated barrel column.
Mots-clé
Action Potentials/physiology Animals Brain Mapping Evoked Potentials, Somatosensory Female Mice Mice, Inbred ICR Models, Biological Multivariate Analysis Neural Inhibition/*physiology Neurons, Afferent/*physiology Physical Stimulation Somatosensory Cortex/*cytology Time Factors Vibrissae/*innervation
Pubmed
Web of science
Création de la notice
24/01/2008 15:41
Dernière modification de la notice
03/03/2018 16:50
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